Arizona Cardinals Face Injury Challenges Ahead of 49ers Matchup

Published
November 14, 2025
Category
NFL
Word Count
366 words
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As the Arizona Cardinals prepare to face the San Francisco 49ers, they are grappling with a lengthy injury report that raises serious concerns about their competitive edge. According to Revenge of the Birds, the team's injury list has reached a critical level, with significant players unavailable for the upcoming matchup. Notably, Marvin Harrison Jr. will miss the game after undergoing an appendectomy this week. Additionally, defensive end Josh Sweat has been designated as a DNP due to rest, which raises worries about his availability. Other players like Will Johnson, Jonah Williams, Baron Browning, Mack Wilson Sr., and Dadrion Taylor-Demerson also missed practice, casting further doubt on their participation against the 49ers. The overall situation leaves the Cardinals with a troubling roster heading into this crucial game.

On the other side, the San Francisco 49ers are entering this game determined to rebound from a disappointing 42-26 loss to the Los Angeles Rams. They currently sit at 6-4 and are looking to secure a playoff spot as they navigate a pivotal stretch in their schedule. The 49ers are in need of a strong performance, particularly with their upcoming matchups against the Cardinals and the Panthers presenting opportunities to improve their standings. As the 49ers aim for a four-game winning streak to solidify their playoff chances, they are aware of the challenges posed by the injury-ravaged Cardinals.

The Cardinals are in a precarious position, as their injury woes could hinder their aspirations to salvage the season. The team, which is in its third year of a rebuild, is now playing for pride, as noted by Revenge of the Birds. With key players sidelined, the lack of depth and experience could prove detrimental against a 49ers team poised to take advantage of any weaknesses.

As the Cardinals gear up for this matchup, the stakes are high not just for the 49ers, who are vying for a playoff spot, but also for the Cardinals, who face the prospect of further setbacks if they cannot field a competitive team. The combination of the Cardinals' injuries and the 49ers' need for a strong performance sets the stage for a compelling game that could have significant ramifications for both teams as the season progresses.

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