LATE Dementia Research Reveals Impact on Alzheimer's Symptoms

Recent research is reshaping the understanding of cognitive decline, particularly regarding a newly recognized form of dementia known as LATE, or Limbic-predominant age-related TDP-43 encephalopathy. This condition, while less severe than Alzheimer's disease, has been found to exacerbate Alzheimer's symptoms when both disorders are present.

According to Dr. Greg Jicha, a neurologist and associate director at the University of Kentucky's Sanders-Brown Center on Aging, approximately one in five patients initially diagnosed with Alzheimer's may actually have LATE.

This revelation comes in light of new diagnostic guidelines published this year, which indicate that LATE affects about 10 percent of individuals aged 65 and older and approximately one-third of those aged 85 and older.

Dr. Pete Nelson, also an associate director at the Sanders-Brown Center, notes that LATE progresses more slowly than Alzheimer's, providing some reassurance to patients and their families. However, there is currently no specific treatment for LATE, highlighting the need for a broader range of therapeutic approaches.

This evolving understanding underscores the complexities of dementia, as many older adults exhibit multiple forms of dementia pathology. The research indicates that the presence of LATE alongside Alzheimer's can significantly speed up cognitive decline and worsen symptoms.

As awareness increases and diagnostic practices improve, the distinction between LATE and Alzheimer's becomes crucial for effective patient care.